Pyribenzamine is an antihistamine used to treat allergies. It is a prescription drug that may be used for either seasonal allergies or everyday allergies, and it can cause Xerostomia or dry mouth.
Pyribenzamine (PBZ) (tripelennamine)
The International Non-proprietary Name (INN) of this prescription drug, which may cause cotton mouth, is tripelennamine. One of the brand names for tripelennamine in the United States is Pyribenzamine. This antihistamine which can cause Xerostomia is also sold as PBZ-SR and PBZ.
Generic versions of tripelennamine are also available to allergy sufferers.
Uses for Pyribenzamine
Pyribenzamine is used to treat allergies that affect both the body’s airways and allergic skin reactions. The antihistamine in tripelennamine blocks histamines, which can cause mild discomfort, including a runny nose. The tripelennamine is also used to treat allergic reactions which affect the skin, including itchy hives and rashes.
People who suffer from asthma or hay fever may be prescribed Pyribenzamine. Pyribenzamine’s popularity is decreasing because there are newer antihistamines on the market.
Pyribenzamine comes in tablet form. It may also be delivered to the allergy sufferer topically.
Adverse reactions that may be experienced when taking Pyribenzamine include, “Drowsiness, gastric discomfort, nausea and dry mouth,” according to RxMed.com.
Dry mouth, or Xerostomia, is when there is little to no saliva in the mouth, creating a cotton mouth feeling. Xerostomia can be a temporary, adverse reaction to the tripelennamine. Saliva production should return to normal when the patient is no longer taking the drug.
Sustained Xerostomia and Health
Sustained Xerostomia due to Pyribenzamine can contribute to deteriorated oral health. Chronic use of tripelennamine may increase the chances of oral candidiasis. While using Xerostomia, plaque is more likely to develop.
Xerostomia may also contribute to both gum disease and tooth loss, according to the California Dental Hygienists’ Association.
Dry Mouth and Dental Health
While taking Pyribenzamine, or any medication which causes a dry mouth feeling, patients need to take extra care to brush after meals and to floss daily.
For those who need to take tripelennamine on a regular basis and are suffering from cotton mouth, a replacement therapy may be in order. Contact your doctor or dentist to find out which prescription saliva replacement therapy might help without negatively interacting with the tripelennamine.
Greenspan D. Xerostomia: Diagnosis and management. Oncology 1996;10 (Suppl): 7-11.
California Dental Hygienists’ Association. Xerostomia: Dry mouth. [www document] (October 25, 2000).